Identification of a heat-inducible novel nuclear body containing the long noncoding RNA <i>MALAT1</i>
نویسندگان
چکیده
ABSTRACT The heat-shock response is critical for the survival of all organisms. Metastasis-associated long adenocarcinoma transcript 1 (MALAT1) a noncoding RNA localized in nuclear speckles, but its physiological role remains elusive. Here, we show that heat shock induces translocation MALAT1 to distinct body named shock-inducible RNA-containing (HiNoCo) mammalian cells. MALAT1-knockout A549 cells showed reduced proliferation after shock. HiNoCo body, which formed adjacent from any other known bodies, including stress Cajal germs, paraspeckles, nucleoli and promyelocytic leukemia body. formation reversible independent factor 1, master transcription regulator response. Our results suggest participates 1-independent responses
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2021
ISSN: ['1477-9137', '0021-9533']
DOI: https://doi.org/10.1242/jcs.253559